Essentials of Stem Cell Biology (3rd Edition)


Download Essentials of Stem Cell Biology (3rd Edition) written by Robert Lanza, Anthony Atala in PDF format. This book is under the category Biology and bearing the isbn/isbn13 number 124095038/9780124095038. You may reffer the table below for additional details of the book.

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First developed as an accessible abridgment of the successful Handbook of Stem Cells; Essentials of Stem Cell Biology; 3rd edition (PDF) serves the needs of the evolving population of researchers; scientists; practitioners; and university students embracing the latest advances in stem cells. Representing the combined effort of 7 editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells; this ebook combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world’s experts of the latest research information about specific organ systems. From basic mechanisms/biology; early development; mesoderm; endoderm; ectoderm; and methods to the application of stem cells to specific human diseases; patient perspectives; and regulation and ethics; no topic in the field of stem cells is left uncovered.


    • Contributions by Nobel Laureates and leading international investigators


    • Presented in full color with highlighted terms; a glossary; and bibliographic entries replacing references


    • Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough


    • Edited by a world-renowned author and researcher to present a complete story of stem cells in research; in an application; and as the subject of political debate




“…serves the needs of the evolving population of researchers; practitioners; scientists; and students embracing the latest advances in stem cells…From basic biology; early development; mesoderm; endoderm; ectoderm; and methods to the application of stem cells to specific regulation and ethics; human diseases; and patient perspectives; no topic in the field of stem cells is left uncovered.” — Anticancer Research 34; 2014

“This ebook offers a thorough review of current research and therapeutic potential in the field of stem cell biology. The focus is on the therapeutic potential of stem cells; with the discussion of the current state of stem cell knowledge and stem cell therapies in various tissues and organs…any scientists interested in studying the field would benefit from this ebook’s thorough treatment of the subject.” —; March 7; 2014


Additional information


Robert Lanza, Anthony Atala


Academic Press




665 pages









Table of contents

Front-matter, Pages i,iii
Copyright, Page iv
Foreword, Pages xix-xx, Sir Martin Evans
Preface, Page xxi, Robert Lanza
List of Contributors, Pages xxiii-xxviii, Russell C. Addis, Piero Anversa, Judith Arcidiacono, Anthony Atala, Joyce Axelman, Ashok Batra, Helen M. Blau, Susan Bonner-Weir, Mairi Brittan, Hal E. Broxmeyer, Mara Cananzi, Constance Cepko, Tao Cheng, Susana M. Chuva de Sousa Lopes, Gregory O. Clark, Maegen Colehour, Paolo de Coppi, Giulio Cossu, George Q. Daley, Jiyoung M. Dang, et al.
Chapter 1 – Why Stem Cell Research? Advances in the Field, Pages 3-6, Alan Trounson
Chapter 2 – ‘Stemness’: Definitions, Criteria, and Standards, Pages 7-17, Douglas Melton
Chapter 3 – Pluripotent Stem Cells from Vertebrate Embryos: Present Perspective and Future Challenges, Pages 19-34, Richard L. Gardner
Chapter 4 – Embryonic Stem Cells in Perspective, Pages 35-38, Janet Rossant
Chapter 5 – The Development of Epithelial Stem Cell Concepts, Pages 39-56, Christopher S. Potten, James W. Wilson
Chapter 6 – Stem Cell Niches, Pages 59-79, D. Leanne Jones, Margaret T. Fuller
Chapter 7 – Mechanisms of Stem Cell Self-Renewal, Pages 81-94, Hitoshi Niwa
Chapter 8 – Cell Cycle Regulators in Stem Cells, Pages 95-106, Tao Cheng, David T. Scadden
Chapter 9 – How Cells Change Their Phenotype, Pages 107-117, David Tosh, Marko E. Horb
Chapter 10 – Differentiation in Early Development, Pages 121-139, Susana M. Chuva de Sousa Lopes, Christine L. Mummery
Chapter 11 – Stem Cells Derived from Amniotic Fluid, Pages 141-156, Mara Cananzi, Anthony Atala, Paolo de Coppi
Chapter 12 – Stem and Progenitor Cells Isolated from Cord Blood, Pages 157-161, Hal E. Broxmeyer
Chapter 13 – The Nervous System, Pages 163-184, Lorenz Studer
Chapter 14 – Sensory Epithelium of the Eye and Ear, Pages 185-202, Constance Cepko, Donna M. Fekete
Chapter 15 – Epithelial Skin Stem Cells, Pages 203-218, Tudorita Tumbar, Elaine Fuchs
Chapter 16 – Hematopoietic Stem Cells, Pages 219-226, George Q. Daley
Chapter 17 – Peripheral Blood Stem Cells, Pages 227-244, Zhan Wang, Gunter Schuch, J. Koudy Williams, Shay Soker
Chapter 18 – Multipotent Adult Progenitor Cells, Pages 245-253, Philip R. Roelandt, Valerie D. Roobrouck, Catherine M. Verfaillie
Chapter 19 – Mesenchymal Stem Cells, Pages 255-266, Zulma Gazit, Gadi Pelled, Dima Sheyn, Nadav Kimelman, Dan Gazit
Chapter 20 – Skeletal Muscle Stem Cells, Pages 267-279, Mark A. LaBarge, Helen M. Blau
Chapter 21 – Stem Cells and the Regenerating Heart, Pages 281-289, Nadia Rosenthal, Maria Paola Santini
Chapter 22 – Cell Lineages and Stem Cells in the Embryonic Kidney, Pages 291-308, Gregory R. Dressler
Chapter 23 – Adult Liver Stem Cells, Pages 309-327, Markus Grompe
Chapter 24 – Pancreatic Stem Cells, Pages 329-342, Yuval Dor, Douglas A. Melton
Chapter 25 – Stem Cells in the Gastrointestinal Tract, Pages 343-371, Sean Preston, Nicholas A. Wright, Natalie Direkze, Mairi Brittan
Chapter 26 – Induced Pluripotent Stem Cells, Pages 375-385, Keisuke Okita, Shinya Yamanaka
Chapter 27 – Embryonic Stem Cells: Derivation and Properties, Pages 387-398, Junying Yu, James A. Thomson
Chapter 28 – Isolation and Maintenance of Murine Embryonic Stem Cells, Pages 399-408, Martin Evans
Chapter 29 – Approaches for Derivation and Maintenance of Human Embryonic Stem Cells: Detailed Procedures and Alternatives, Pages 409-434, Irina Klimanskaya, Jill McMahon
Chapter 30 – Derivation and Differentiation of Human Embryonic Germ Cells, Pages 435-451, Michael J. Shamblott, Candace L. Kerr, Joyce Axelman, John W. Littlefield, Gregory O. Clark, Ethan S. Patterson, Russell C. Addis, Jennifer N. Kraszewski, Kathleen C. Kent, John D. Gearhart
Chapter 31 – Genomic Reprogramming, Pages 453-463, M. Azim Surani
Chapter 32 – Neural Stem Cells – Therapeutic Applications in Neurodegenerative Diseases, Pages 467-489, Rodolfo Gonzalez, Yang D. Teng, Kook I. Park, Jean Pyo Lee, Jitka Ourednik, Vaclav Ourednik, Jaimie Imitola, Franz-Josef Mueller, Richard L. Sidman, Evan Y. Snyder
Chapter 33 – Adult Progenitor Cells as a Potential Treatment for Diabetes, Pages 491-500, Susan Bonner-Weir, Gordon C. Weir
Chapter 34 – Burns and Skin Ulcers, Pages 501-513, Holger Schlüter, Edward Upjohn, George Varigos, Pritinder Kaur
Chapter 35 – Stem Cells and Heart Disease, Pages 515-528, Piero Anversa, Annarosa Leri, Bernardo Nadal-Ginard, Jan Kajstura
Chapter 36 – Stem Cells for the Treatment of Muscular Dystrophy, Pages 529-542, Francesco Saverio Tedesco, Maurilio Sampaolesi, Giulio Cossu
Chapter 37 – Cell Therapy for Liver Disease: From Hepatocytes to Stem Cells, Pages 543-564, Stephen C. Strom, Ewa C.S. Ellis
Chapter 38 – Orthopedic Applications of Stem Cells, Pages 565-580, Jerry I. Huang, Jung U. Yoo, Victor M. Goldberg
Chapter 39 – Embryonic Stem Cells in Tissue Engineering, Pages 581-592, Shulamit Levenberg, Ali Khademhosseini, Robert Langer
Chapter 40 – Ethical Considerations, Pages 595-604, Ronald M. Green
Chapter 41 – Overview of the FDA Regulatory Process, Pages 605-634, Mark H. Lee, Kevin J. Whittlesey, Jiyoung M. Dang, Maegen Colehour, Judith Arcidiacono, Ellen Lazarus, David S. Kaplan, Donald Fink, Charles N. Durfor, Ashok Batra, Stephen L. Hilbert, Deborah Lavoie Grayeski, Richard McFarland, Celia Witten
Chapter 42 – It’s Not about Curiosity, It’s about Cures: Stem Cell Research – People Help Drive Progress, Pages 635-644, Mary Tyler Moore, S.Robert Levine
Glossary, Pages 645-660
Index, Pages 661-680

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